Immunological Signaling During Herpes Simplex Virus-2 and Cytomegalovirus Vaginal Shedding After Initiation of Antiretroviral Treatment
| Autor: | Sara Gianella, Eshan U. Patel, Paschal Ssebbowa, Sarah Kalibbala, Martha Nason, Rupert Kaul, Allison R. Kirkpatrick, Jessica L. Prodger, Aaron A.R. Tobian, Andrew D. Redd, Kamnoosh Shahabi, David Serwadda, Ronald H. Gray, Thomas C. Quinn, Steven J. Reynolds |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
viral shedding 030106 microbiology Congenital cytomegalovirus infection medicine.disease_cause Herpesviridae Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Aldesleukin medicine 030212 general & internal medicine Viral shedding Interleukin 6 Cytokine biology business.industry CMV HIV HSV-2 medicine.disease Virology 3. Good health Interleukin 10 Infectious Diseases Herpes simplex virus Oncology Immunology biology.protein Brief Reports business |
| Zdroj: | Open Forum Infectious Diseases |
| ISSN: | 2328-8957 |
| DOI: | 10.1093/ofid/ofw073 |
| Popis: | Vaginal proinflammatory cytokine expression during herpes virus reactivation was examined in human immunodeficiency virus-infected women before and after initiation of antiretroviral therapy (ART). Vaginal swabs were screened for levels of cytokines interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, tumor necrosis factor (TNF)-α, and interferon-γ. The relative risk (RR) of herpes simplex virus-2 or cytomegalovirus (CMV) shedding being associated with cytokine levels above the median were estimated. Herpes simplex virus-2 shedding was significantly associated with higher levels of IL-6 (RR = 1.4, P = .003) and TNF-α (RR = 1.3, P = .010), whereas CMV shedding was associated with higher IL-6 (RR = 1.3, P = .006) and IL-2 (RR = 1.4, P = .01). The association of viral shedding with higher IL-6 levels suggests that herpes virus reactivation may be playing a role in immune activation after ART initiation. |
| Databáze: | OpenAIRE |
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