Evidence of a monoaminergic-cholinergic imbalance related to visual hallucinations in Lewy body dementia
| Autor: | Elaine K. Perry, Elizabeth F. Marshall, Janet Kerwin, Anthony V. Cheng, Carthage J. Smith, Robert H. Perry, S. Jabeen |
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| Rok vydání: | 1990 |
| Předmět: |
Male
Biogenic Amines Hallucinations Receptors Nicotinic Serotonergic Biochemistry Choline O-Acetyltransferase Cellular and Molecular Neuroscience Neurochemical Reference Values Monoaminergic medicine Humans Aged Temporal cortex Aged 80 and over Lewy body Homovanillic Acid Hydroxyindoleacetic Acid medicine.disease Choline acetyltransferase Receptors Muscarinic Acetylcholine Temporal Lobe Hallucinating Visual Perception Cholinergic Dementia Female Autopsy Ketanserin Psychology Neuroscience |
| Zdroj: | Journal of neurochemistry. 55(4) |
| ISSN: | 0022-3042 |
| Popis: | Senile dementia of Lewy body type is characterized clinically by a relatively acute onset of fluctuating memory loss and confusion, frequently accompanied by visual hallucinations. Neurochemical analyses of temporal cortex has revealed a distinction between hallucinating and nonhallucinating patients in both cholinergic and monaminergic transmitter activities. In contrast with the cholinergic enzyme choline acetyltransferase, which was more extensively reduced in hallucinating individuals, serotonergic S2 receptor binding and both dopamine and serotonin metabolites were significantly decreased in nonhallucinating cases. These results suggest that an imbalance between monaminergic and cholinergic transmitters is involved in hallucinogenesis in the human brain. |
| Databáze: | OpenAIRE |
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