High Serum Uric Acid and High-Sensitivity C Reactive Protein Concentrations Predict Three-Year Cardiovascular Mortality in Patients Treated With Continuous Ambulatory Peritoneal Dialysis
| Autor: | Quyen Dao Bui Quy, Tuan Pham Ngoc Huy, Tuan Nguyen Minh, Loc Nguyen Duc, Kien Nguyen Trung, Tien Tran Viet, Quyet Do, Thang Le Viet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
predicting
medicine.medical_specialty cardiovascular-related mortality Therapeutics Gastroenterology chemistry.chemical_compound hs-crp uric acid Internal medicine Diabetes mellitus medicine Internal Medicine capd Stroke biology Proportional hazards model business.industry C-reactive protein High serum Continuous ambulatory peritoneal dialysis General Engineering Area under the curve medicine.disease chemistry Nephrology biology.protein Uric acid business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Aims: This study aims to access the predicting value of serum uric acid (UA) and high-sensitivity C reactive protein (hs-CRP) concentration on three-year cardiovascular-related mortality in patients performing continuous ambulatory peritoneal dialysis (CAPD). Methods: A total of267 CAPD patients [150 male (56.2%); mean age 48.93 ± 13.58 years] were included in our study. All patients had measured serum UA and hs-CRP concentration. A high-sensitivity particle-enhanced immunoturbidimetric assay determined serum hs-CRP; serum UA levels were determined using an enzymatic colorimetric assay. All patients were followed for three years to detect cardiovascular-related mortality by cardiologists and stroke specialists. Results: Mean serum UA level was 415.16 ± 84.28 µmol/L, 58.4% of patients had increased serum UA level. Median serum hs-CRP level was 2 (1-4) mg/L, 12.4% of patients had increased serum hs-CRP level. During 36 months of follow-up, 41 patients (15.4%) had cardiovascular-related mortality. The results of Cox proportional hazards regression showed that hypertension, diabetes, high serum UA and hs-CRP were risk factors that related to cardiovascular-related mortality (p |
| Databáze: | OpenAIRE |
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