Malignant Peritoneal Mesothelioma: Patterns of Care and Survival in the Netherlands: A Population-Based Study
| Autor: | Nadine L. de Boer, Joachim G.J.V. Aerts, Ronald A. M. Damhuis, Cornelis Verhoef, Job P. van Kooten, Eva V. E. Madsen |
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| Přispěvatelé: | Surgery, Pulmonary Medicine |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male Mesothelioma medicine.medical_specialty Lung Neoplasms Adolescent Pleural Neoplasms Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine SDG 3 - Good Health and Well-being Surgical oncology Internal medicine Medicine Humans 030212 general & internal medicine Registries Child Survival rate Survival analysis Peritoneal Neoplasms Aged Netherlands Proportional hazards model business.industry Hazard ratio Mesothelioma Malignant Infant Newborn Infant Hyperthermia Induced Middle Aged Prognosis Combined Modality Therapy Cancer registry Survival Rate 030220 oncology & carcinogenesis Child Preschool Surgery Hyperthermic intraperitoneal chemotherapy Female Health Services Research and Global Oncology business Cohort study Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology, 26:WOS:000506884200016, 4222-4228. Springer New York Annals of Surgical Oncology |
| ISSN: | 1068-9265 |
| Popis: | Background Malignant peritoneal mesothelioma (MPM) is a rare and aggressive disease. Recently, focus has shifted toward a more aggressive and multimodal treatment approach. This study aimed to assess the patterns of care and survival for MPM patients in the Netherlands on a nationwide basis. Methods The records of patients with a diagnosis of MPM from 1993 to 2016 were retrieved from the Dutch Cancer Registry. Data regarding diagnosis, staging, treatment, and survival were extracted. Cox regression analyses and Kaplan–Meier survival curves were used to study overall survival. Results Between 1993 and 2016, MPM was diagnosed for 566 patients. Overall, the prognosis was very poor (24% 1-year survival). The most common morphologic subtype was the epithelioid subtype (88%), followed by the biphasic (8%) and sarcomatoid (4%) subtypes. Surgical treatment has become more common in recent years, which most likely has resulted in improved survival rates. In this study, improved survival was independently associated with hyperthermic intraperitoneal chemotherapy (hazard ratio [HR], 0.33; 95% confidence interval [CI], 0.21–0.55) and surgery with adjuvant systemic chemotherapy (HR, 0.33; 95% CI, 0.23–0.48). Nonetheless, most patients (67%) do not receive any form of anti-cancer treatment. Conclusion This study indicated that MPM still is a rare and fatal disease. The survival rates in the Netherlands have improved slightly in the past decade, most likely due to more aggressive treatment approaches and increased use of surgery. However, most patients still do not receive cancer-directed treatment. To improve MPM management, and ultimately survival, care should be centralized in expert medical centers. |
| Databáze: | OpenAIRE |
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