An Evaluation of Antidepressants in Rheumatic Pain Conditions
| Autor: | Rani Pu, Takallapalli Ramesh Kumar Rao, Prasad Vb, Naidu Mu, Shobha Jc |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Amitriptyline medicine.medical_treatment Analgesic Pain Antidepressive Agents Tricyclic Placebo Xerostomia Placebos Double-Blind Method Fluoxetine Rheumatic Diseases medicine Humans Rheumatic pain Pain Measurement Analgesics Chemotherapy business.industry Incidence Parallel study medicine.disease Anesthesiology and Pain Medicine Anesthesia Chronic Disease Antidepressive Agents Second-Generation Female Safety business Selective Serotonin Reuptake Inhibitors Rheumatism medicine.drug |
| Zdroj: | Anesthesia & Analgesia. 83:371-375 |
| ISSN: | 0003-2999 |
| DOI: | 10.1097/00000539-199608000-00029 |
| Popis: | In a randomized, double-blind, parallel study, fluoxetine and amitriptyline were compared with placebo in the treatment of chronic rheumatic pain. A total of 59 patients were evaluated during 4 wk of treatment and received 20 mg fluoxetine, 25 mg amitriptyline, or placebo daily. Pain intensity, pain relief, vital variables, and global evaluation were used to assess efficacy. To evaluate safety variables, the incidence of side effects was noted. Both amitriptyline and fluoxetine significantly reduced pain intensity compared with placebo. Similarly, pain relief was greater with both amitriptyline and fluoxetine than with placebo. At the end of the fourth week, fluoxetine was superior in efficacy to amitriptyline. The incidence of adverse effects was significantly greater with amitriptyline; dryness of the mouth was the most predominant side effect. We conclude that fluoxetine is an effective analgesic with fewer side effects. |
| Databáze: | OpenAIRE |
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