Impaired clearance, elimination, and metabolism of plasma cholesterol esters associated with hypercholesteremia in mice fed cyclopropenoid fatty acids
| Autor: | J.E. Nixon, John P. Matlock |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
food.ingredient Metabolic Clearance Rate Sterol O-acyltransferase Hypercholesterolemia Toxicology Lecithin chemistry.chemical_compound Feces Mice food Animals Pharmacology chemistry.chemical_classification Cholesterol Reverse cholesterol transport Fatty Acids Fatty acid Metabolism Dietary Fats Sterol Kinetics Sterols Biochemistry chemistry Fatty Acids Unsaturated lipids (amino acids peptides and proteins) Cholesterol Esters Lipoproteins HDL Corn oil |
| Zdroj: | Toxicology and applied pharmacology. 84(1) |
| ISSN: | 0041-008X |
| Popis: | Swiss-Webster mice were fed corn oil control diet or 0.7% cyclopropenoid fatty acid (CPFA) for 8 weeks and dosed iv with an equimolar suspension of [ 3 H]cholesteryl palmitate and [ 14 C]cholesteryl palmitoleate. Blood decline of labeled sterol was biphasic. There were no differences in the in vivo plasma cholesterol ester metabolism, elimination kinetics, or fecal elimination rate for labeled sterol from [ 3 H]cholesteryl palmitate or [ 14 C]cholesteryl palmitoleate within CPFA or control groups. However, compared to controls, CPFA animals diverted significantly more labeled sterol into saturated and diunsaturated cholesterol esters, less into mono- and tetraunsaturated esters, and showed decreased blood clearance and fecal elimination of labeled sterol. Biliary elimination was probably not impaired by depressed hepatic cholesterol esterase activity in CPFA-fed mice. The fundamental effect of CPFA on serum cholesterol concentration appears to reside in a severely imbalanced cholesterol esters profile. Results indicate that CPFA alter normal fatty acid profile of serum cholesterol esters by proportionally altering the C-2 fatty acyl composition of serum phospholipid, which is the substrate for lecithin:cholesterol acyltransferase, the major source of plasma cholesterol esters. |
| Databáze: | OpenAIRE |
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