Corrigendum to: Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis
| Autor: | Valérie Pendaries, Guy Serre, Laura Cau, Marie-Claire Méchin, Michel Simon, Carle Paul, Marie Reynier, Laurence Pellerin, Marina Le Lamer, Corinne Leprince |
|---|---|
| Přispěvatelé: | Unité différenciation épidermique et auto-immunité rhumatoïde (UDEAR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), CARBILLET, Véronique |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
filaggrin
keratinocytes Clinical Biochemistry MESH: Proteins / metabolism MESH: Dermatitis Atopic / pathology Biochemistry MESH: Dermatitis Atopic / metabolism corneocytes [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases skin inflammation medicine MESH: Animals Molecular Biology Epidermal barrier Corneocyte MESH: Humans integumentary system atopic dermatitis epidermal barrier Chemistry MESH: Cytokines / metabolism MESH: Epidermis / pathology Atopic dermatitis MESH: Cornea / pathology medicine.disease MESH: Cornea / metabolism 3. Good health Immunology [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases eczema MESH: Epidermis / metabolism |
| Zdroj: | Biological Chemistry Biological Chemistry, De Gruyter, 2016, 396 (11), pp.1163-1179. ⟨10.1515/hsz-2016-0116⟩ Biological Chemistry, 2016, 396 (11), pp.1163-1179. ⟨10.1515/hsz-2016-0116⟩ |
| ISSN: | 1431-6730 1437-4315 |
| DOI: | 10.1515/hsz-2016-0116⟩ |
| Popis: | International audience; The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2-3% of adults and often precedes the development of allergic rhinitis and asthma. This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components. The consequences of the epidermal barrier alteration on our current understanding of the pathogenesis of AD, and its possible implications on the treatment of patients, are discussed here. |
| Databáze: | OpenAIRE |
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