Use of anti-dementia drugs in home care and residential care and associations with neuropsychiatric symptoms: a cross-sectional study

Autor: Irma Nykänen, Hannu Koponen, Pertti Karppi, Sirpa Hartikainen, Marja Kuronen
Přispěvatelé: Clinicum, Department of Psychiatry, HUS Psychiatry
Rok vydání: 2015
Předmět:
Male
Activities of daily living
Cross-sectional study
medicine.medical_treatment
GERIATRIC CARE
BEHAVIORAL-PROBLEMS
Residential Facilities
0302 clinical medicine
Surveys and Questionnaires
Activities of Daily Living
Apathy
030212 general & internal medicine
Finland
Nootropic Agents
Aged
80 and over
Rehabilitation
Mental Disorders
Memantine
Middle Aged
Home Care Services
3. Good health
SEVERE ALZHEIMERS-DISEASE
Population study
Female
medicine.symptom
medicine.drug
Research Article
medicine.medical_specialty
PSYCHOLOGICAL SYMPTOMS
03 medical and health sciences
mental disorders
MANAGEMENT
medicine
Dementia
Humans
Psychiatry
Aged
business.industry
CONSORTIUM
medicine.disease
OLD-PEOPLE
Mood
Cross-Sectional Studies
3121 General medicine
internal medicine and other clinical medicine
MODERATE
Cholinesterase Inhibitors
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
Zdroj: BMC Geriatrics
ISSN: 1471-2318
Popis: Background: The number of people with dementia is increasing alongside the aging population, and most of these patients manifest with neuropsychiatric symptoms (NPS). The objective of this study was to investigate anti-dementia drug use and its associations with NPS. Methods: Questionnaires on demographic information, current drug use, activities of daily living and NPS were sent to all municipal home care producers and to all institutions providing long-term residential care in the South Savo Hospital District, Finland. Results: The study population comprised 2821 persons. Their mean age was 81 years and 68 % were female. Dementia had been diagnosed in 31 % (n = 410) in home care and in 56 % (n = 774) in residential care. Anti-dementia drugs were used by 69 % of patients with dementia. Hyperactivity symptoms were common in residential care patients (n = 456, 33 %), while problems with mood and apathy dominated in home care patients (n = 486, 54 %). In multivariate regression analysis, the mood symptoms and apathy subgroup was associated with use of an acetylcholinesterase inhibitor (AChEI) (OR 1.44; 95 % Cl 1.03-2.02), memantine (OR 1.77, 95 % Cl 1.15-2.72) or their combinations (OR 1.56, 95 % Cl 1.03-2.34). Hyperactivity symptoms were associated with combination therapy of this type (OR 2.03, 95 % Cl 1.36-2.34). Conclusions: The use of anti-dementia drugs was common in both care settings. The use of any anti-dementia drug or combination was associated with the mood and apathy subgroup. The hyperactivity subgroup was associated with combination use of memantine and AChEI.
Databáze: OpenAIRE
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