Production of TNF-alpha ex vivo is predictive of an immune response to flu vaccination in a frail elderly population
| Autor: | Michael G. Tovey, Corinne Desaint, Odile Launay, Bénédicte Charmeteau, J.-F. Meritet, Pierre Lebon, Frédéric Bloch |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Clinical Biochemistry Immunology Population Antibodies Viral 03 medical and health sciences 0302 clinical medicine Immune system Interferon Influenza Human Humans Immunology and Allergy Medicine Frail elderly education Cells Cultured Aged Aged 80 and over 030203 arthritis & rheumatology education.field_of_study Tumor Necrosis Factor-alpha business.industry Vaccination social sciences Molecular medicine humanities 030104 developmental biology Influenza A virus Influenza Vaccines Cytokines Female Tumor necrosis factor alpha business Ex vivo medicine.drug |
| Zdroj: | European Cytokine Network. 27:63-67 |
| ISSN: | 1148-5493 |
| DOI: | 10.1684/ecn.2016.0378 |
| Popis: | To investigate the relationship between the response to influenza vaccination and the ability to produce proinflamatory cytokines in elderly subjects.Whole blood samples from 25 elderly subjects collected before influenza vaccination were stimulated with the influenza vaccine in order to evaluate the secretion of five specific cytokines: TNFα, IFNα, IFNγ, IL2 and IL10. The results were correlated with the increased HAI antibody titres two weeks after vaccination.Only 30% of elderly individuals seroconverted after vaccination. Although 50 to 70% of the cohort did not produce TNFα, IFNα, IFNγ, IL2 or IL10, all of the individuals who seroconverted were able to produce TNFα. Furthermore production of IFNγ, with or without production of IFNα/β, was not associated with a better response to the vaccine.Production of TNFα appears to be primordial for an efficient vaccine response, and may provide a predictive marker for the humoral response to vaccination. It may also provide the basis for evaluating agents designed to rescue TNFα-producing cells. This study emphasises a need to rescue TNF-producing cell function. |
| Databáze: | OpenAIRE |
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