Are the anatomical, clinical, and ultrasound characteristics of thyroid nodules with Bethesda III or IV cytology and ACR TI-RADS 3, 4, or 5 able to refine the indications for molecular diagnostic tests?
| Autor: | Tarcizo Afonso Nunes, Magda Carvalho Pires, Camila Teixeira Costa, Gustavo Cancela e Penna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Thyroid nodules
medicine.medical_specialty molecular tests Endocrinology Diabetes and Metabolism medicine.medical_treatment molecular diagnostic tests Malignancy Diseases of the endocrine glands. Clinical endocrinology Thyroid carcinoma indeterminate nodules indeterminate thyroid nodules medicine Atypia Humans Thyroid Neoplasms Thyroid Nodule Family history Pathology Molecular Thyroid cancer Retrospective Studies Ultrasonography business.industry Thyroidectomy Nodule (medicine) Middle Aged medicine.disease RC648-665 Medicine Female Radiology medicine.symptom business |
| Zdroj: | Archives of Endocrinology and Metabolism, Volume: 65, Issue: 5, Pages: 625-631, Published: 29 SEP 2021 Archives of Endocrinology and Metabolism v.65 n.5 2021 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM Archives of Endocrinology and Metabolism, Issue: ahead, Published: 25 OCT 2021 Archives of Endocrinology and Metabolism, Vol 65, Iss 5, Pp 625-631 (2021) |
| Popis: | Objective: To analyze the association of clinical, anatomical, and ultrasound (US) characteristics of malignancies in Bethesda III or IV (III-B or IV-B) thyroid nodules. Subjects and methods: The association between malignancies and the following variables were analyzed: III-B or IV-B, age < 55 years and ≥ 55 years, sex, family history of thyroid cancer, history of irradiation, nodule size, and ACR TI-RADS classification in 62 participants who underwent thyroidectomy. Results: Of the 62 participants, 87.1% (54/62) were women, 74.2% were < 55 years old, 95.2% had no family history of thyroid cancer, 56.5% had nodules < 2 cm in size, 62.9% were IV-B, and 69.4% were ACR TI-RADS 4. Thirty-two patients had thyroid carcinoma, and 30 had benign histology. Among all factors associated with malignancy, only ACR TI-RADS 5 classification on US was found to be statistically significant (p = 0.014), while III-B with architectural atypia cytological classification was the only one significantly associated with benign status (p = 0.004). Conclusion: Only a high risk of malignancy as assessed using US was able to refine the indication for molecular tests in a group of patients with indeterminate nodules. We found 85% (53/62) of III-B or IV-B thyroid nodules would benefit from available molecular diagnostic tests. |
| Databáze: | OpenAIRE |
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