Pre-hospital Resuscitation with HBOC-201 and rFVIIa Compared to HBOC-201 Alone in Uncontrolled Hemorrhagic Shock in Swine
| Autor: | Ashraful Haque, Charles R. Auker, Francoise Arnaud, Kohsuke Teranishi, Richard M. McCarron, Bobby Kim, Tomoaki Okada, Paula F. Moon-Massat, Anke H. Scultetus, Daniel Freilich |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Resuscitation Swine Biomedical Engineering Factor VIIa Shock Hemorrhagic Blood substitute Hemoglobins Blood loss Blood Substitutes Internal medicine Statistical significance medicine Dose escalation Animals Drug Interactions Intensive care medicine Liver injury Blood Volume Hematology business.industry medicine.disease Survival Analysis Hospitals Recombinant Proteins Oxygen Anesthesia Hemorrhagic shock Fluid Therapy Female business Biotechnology |
| Zdroj: | Artificial Cells, Blood Substitutes, and Biotechnology. 40:44-55 |
| ISSN: | 1532-4184 1073-1199 |
| Popis: | In a previous dose escalation study our group found that combining 90μg/kg rFVIIa with HBOC-201 reduced blood loss and improved physiologic parameters compared to HBOC alone. In this follow-up study in a swine liver injury model, we found that while there were no adverse hematology effects and trends observed in the previous study were confirmed, statistical significance could not be reached. Additional pre-clinical studies are indicated to identify optimal components of a multifunctional blood substitute for clinical use in trauma. |
| Databáze: | OpenAIRE |
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