Insulin resistance is not a relevant predictor of sustained virological response to pegylated interferon plus ribavirin in HIV/HCV co-infected patients
Autor: | Josefa Ruiz-Morales, Nicolás Merchante, Jesús Sanz-Sanz, Juan Macías, Elisa Fernández-Fuertes, José A. Mira, Ignacio de los Santos-Gil, Mercedes González-Serrano, Dolores Merino, José del Valle, Juan A. Pineda, Antonio Moro |
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Rok vydání: | 2009 |
Předmět: |
Adult
Male medicine.medical_specialty Hepacivirus Hepatitis C virus Alpha interferon HIV Infections Interferon alpha-2 medicine.disease_cause Antiviral Agents Gastroenterology Body Mass Index Polyethylene Glycols chemistry.chemical_compound Insulin resistance Predictive Value of Tests Pegylated interferon Internal medicine Ribavirin medicine Humans Retrospective Studies Hepatology biology business.industry Interferon-alpha Hepatitis C Viral Load biology.organism_classification medicine.disease Recombinant Proteins Treatment Outcome chemistry Immunology RNA Viral Female Insulin Resistance business Viral load medicine.drug |
Zdroj: | Journal of Hepatology. 50:684-692 |
ISSN: | 0168-8278 |
DOI: | 10.1016/j.jhep.2008.10.032 |
Popis: | To evaluate the possible influence of baseline insulin resistance in sustained virological response.One hundred and fifty-five consecutive individuals from a multicentric cohort of HIV/HCV co-infected patients who underwent therapy with pegylated interferon plus ribavirin were included. The main outcome variable was sustained virological response, defined as undetectable plasma HCV RNA at week 24 after the end of the therapy. Insulin resistance was determined using the HOMA method.Sustained virological response was achieved in 55 (36%) patients. Forty-two (38%) patients with a HOMA lower than 4 developed sustained virological response vs 13 (29%) of those with a HOMA above 4 (p=0.27). Analyses restricted to patients harbouring genotype 1 or 4 showed similar rates of sustained virological response among patients with a HOMA below and above 4 [19 (27%) vs 7 (24%); p=0.8]. In the multivariate analysis, genotype 3 [AOR 9.26; 95% CI 3.03-28.30; p0.0001], a baseline HCV viral load below 600.000IU/mL [AOR 2.97; 95% CI 1.03-8.57; p=0.04] and baseline LDL cholesterol above 100mg/dL [AOR 6.62; 95% CI 1.97-22.19; p=0.002] were independently associated with sustained virological response.Insulin resistance is not a relevant predictor of sustained virological response to pegylated interferon plus ribavirin in HIV/HCV co-infected patients. |
Databáze: | OpenAIRE |
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