Arousal-induced cortical activity triggers lactate release from astrocytes
| Autor: | Marc Zuend, Jordi Duran, Bruno Weber, Aiman S. Saab, Ladina Hösli, Kim David Ferrari, Jillian L. Stobart, Matthias T. Wyss, Joan J. Guinovart, L. Felipe Barros, Zoe J Looser |
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| Přispěvatelé: | University of Zurich, Weber, Bruno |
| Rok vydání: | 2018 |
| Předmět: |
Endocrinology
Diabetes and Metabolism 10050 Institute of Pharmacology and Toxicology 610 Medicine & health Arousal 1307 Cell Biology chemistry.chemical_compound Mice 2737 Physiology (medical) In vivo Physiology (medical) Receptors Adrenergic beta Internal Medicine Extracellular Memory formation Animals Lactic Acid Cerebral Cortex Lactate concentration Glycogen Glycogen metabolism Electroencephalography Cell Biology Cell biology 2712 Endocrinology Diabetes and Metabolism chemistry 2724 Internal Medicine Astrocytes 570 Life sciences biology Intracellular Signal Transduction |
| Zdroj: | Nature metabolism. 2(2) |
| ISSN: | 2522-5812 |
| Popis: | It has been suggested that, in states of arousal, release of noradrenaline and β-adrenergic signalling affect long-term memory formation by stimulating astrocytic lactate production from glycogen. However, the temporal relationship between cortical activity and cellular lactate fluctuations upon changes in arousal remains to be fully established. Also, the role of β-adrenergic signalling and brain glycogen metabolism on neural lactate dynamics in vivo is still unknown. Here, we show that an arousal-induced increase in cortical activity triggers lactate release into the extracellular space, and this correlates with a fast and prominent lactate dip in astrocytes. The immediate drop in astrocytic lactate concentration and the parallel increase in extracellular lactate levels underline an activity-dependent lactate release from astrocytes. Moreover, when β-adrenergic signalling is blocked or the brain is depleted of glycogen, the arousal-evoked cellular lactate surges are significantly reduced. We provide in vivo evidence that cortical activation upon arousal triggers lactate release from astrocytes, a rise in intracellular lactate levels mediated by β-adrenergic signalling and the mobilization of lactate from glycogen stores. |
| Databáze: | OpenAIRE |
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