P3 Component as a Potential Endophenotype for Control Inhibition in Offspring of Alcoholics
| Autor: | Ana Sion, Gabriel Rubio, Isabel Domínguez-Centeno, Gabriela Castillo-Parra, Rosa Jurado-Barba, Francisco López-Muñoz, Andrés Martínez-Maldonado, Isabel Martínez-Gras |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endophenotypes Offspring media_common.quotation_subject Electroencephalography Audiology 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Child of Impaired Parents Event-related potential Reaction Time medicine Humans 0501 psychology and cognitive sciences Alcoholics Family history media_common medicine.diagnostic_test Addiction 05 social sciences Alcohol dependence General Medicine Event-Related Potentials P300 Alcoholism Inhibition Psychological Cross-Sectional Studies Frontal lobe Endophenotype Female Psychology Photic Stimulation 030217 neurology & neurosurgery |
| Zdroj: | Alcohol and Alcoholism. 53:699-706 |
| ISSN: | 1464-3502 0735-0414 |
| Popis: | Aims To assess inhibitory processes and the ongoing event-related potential (ERP) activity of offspring of alcoholics (OA) during a Go/No-Go task, with the purpose of characterizing possible psychophysiological endophenotypes for alcohol-dependent vulnerability. Short summary EEG recordings and ERP measurements of young adults with positive and negative family history of alcoholism where obtained while they performed a Go/No-Go task to assess inhibitory processes. Offspring of alcoholics showed a different ERP pattern compared to the control group and exerted greater effort than the control group. Methods ERP measurements were obtained by electroencephalogram (EEG) recordings of 65 participants divided into two groups: one group of 30 subjects with positive family history of alcoholism and a control group of 35 subjects with negative family history of alcoholism. They performed a Go/No-Go task, where each individual was required to classify visual stimuli by colour (Go) and inhibit their response to a No-Go signal. Results OA have higher P3 amplitudes during the Go condition in all of the regions analysed and higher No-Go P3 amplitudes than control subjects in the frontal region. Unlike controls, OA have no differences between the P3 amplitudes across conditions. Conclusions The absence of differences between the P3 Go and No-Go observed in the OA group can be interpreted as a possible alteration related with inhibition, in a way that they may need to recruit similar resources for inhibitory and classificational processes for both conditions. Therefore, the P3 component may be considered as a useful endophenotype and a vulnerability marker to develop addictive behaviour. |
| Databáze: | OpenAIRE |
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