White jute (Corchorus capsularis L.) leaf extract has potent leishmanicidal activity against Leishmania donovani
| Autor: | Tapati Chakraborti, Pijush Kanti Pramanik, Asmita Pramanik, Dibyendu Paik |
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| Rok vydání: | 2018 |
| Předmět: |
Corchorus
biology Traditional medicine Chemistry Plant Extracts Phytochemicals Leishmania donovani Antiprotozoal Agents Virulence Intracellular reactive oxygen species biology.organism_classification White (mutation) Plant Leaves Inhibitory Concentration 50 Infectious Diseases Corchorus capsularis Phytochemical ANTILEISHMANIAL DRUGS Parasitology Sulfhydryl Compounds Reactive Oxygen Species IC50 |
| Zdroj: | Parasitology international. 71 |
| ISSN: | 1873-0329 |
| Popis: | In pursuit of effective, safe and affordable antileishmanial drugs, the current study was designed to explore Corchorus capsularis L. leaf extract (CCEx) as an effective leishmanicidal substitute against Leishmania donovani. The leaf extract displays potent antileishmanial activity against L. donovani promastigotes with an IC50 value of 79.00 ± 0.3 μg/ml. CCEx also significantly induces intracellular reactive oxygen species (ROS) with a concomitant decrease in the level of non-protein thiols in virulent parasites. Additionally, CCEx treatment induces substantial morphological alterations in parasites. Moreover, reagent-based phytochemical analysis of the extract revealed the presence of various phytochemical constituents. Further study is underway to identify the bioactive component(s) or fraction(s) of CCEx through bioassay-guided fractionation. |
| Databáze: | OpenAIRE |
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