Correlation of apparent diffusion coefficient with Ki-67 proliferation index in grading meningioma
| Autor: | Senthur Thangasamy, Thomas W. Smith, Richard P. Moser, Deepak Takhtani, Yi Tang, Keith A. Cauley, Sathish Kumar Dundamadappa, Thomas Flood |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Proliferation index Statistics as Topic Sensitivity and Specificity Meningioma otorhinolaryngologic diseases Biomarkers Tumor Meningeal Neoplasms Medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Grading (tumors) Aged Aged 80 and over Neoplasm Grading biology business.industry Reproducibility of Results General Medicine Middle Aged medicine.disease Magnetic Resonance Imaging body regions Ki-67 Antigen Ki-67 biology.protein Histopathology Female business Nuclear medicine Diffusion MRI |
| Zdroj: | AJR. American journal of roentgenology. 202(6) |
| ISSN: | 1546-3141 |
| Popis: | A noninvasive method to predict aggressiveness of high-grade meningiomas would be desirable because it would help anticipate tumor recurrence and improve tumor management and the treatment outcomes. The Ki-67 protein is a marker of tumor proliferation, and apparent diffusion coefficient (ADC) is related to tumor cellularity. Therefore, we sought to determine whether there is a statistically significant correlation between ADC and Ki-67 values in meningiomas and whether ADC values can differentiate various meningioma subtypes.MRI examinations and histopathology of 68 surgically treated meningiomas were retrospectively reviewed. Mean ADC values were derived from diffusion imaging. Correlation coefficients were calculated for mean ADC and Ki-67 proliferation index values using linear regression. An independent unpaired Student t test was used to compare the ADC and Ki-67 proliferation index values from low-grade and more aggressive meningiomas.A statistically significant inverse correlation was found between ADC and Ki-67 proliferation index for low-grade and aggressive meningiomas (r(2) = -0.33, p = 0.0039). ADC values (± SD) of low-grade meningiomas (0.84 ± 0.14 × 10(-3) mm(2)/s) and aggressive (atypical or anaplastic) meningiomas (0.75 ± 0.03 × 10(-3) mm(2)/s) were significantly different (p = 0.0495). Using an ADC cutoff value of 0.70 × 10(-3) mm(2)/s, the sensitivity for diagnosing aggressive meningiomas was 29%, specificity was 94%, positive predictive value was 67%, and negative predictive value was 75%.ADC values correlate inversely with Ki-67 proliferation index and help differentiate low-grade from aggressive meningiomas. |
| Databáze: | OpenAIRE |
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