Antimicrobials: targeting virulence genes necessary for intracellular multiplication

Autor:	Stephan Köhler, Véronique Jubier-Maurin, Jean-Pierre Liautard, Rose-Anne Boigegrain
Rok vydání:	2006
Předmět:	Microbiology (medical) Bacteria Virulence Virulence Factors Intracellular parasite Biology Antimicrobial Pathogenicity Microbiology Anti-Bacterial Agents Infectious Diseases Virology Animals Humans Enzyme Inhibitors Gene Pathogen Intracellular
Zdroj:	Trends in Microbiology. 14:109-113
ISSN:	0966-842X
DOI:	10.1016/j.tim.2006.01.005
Popis:	Intracellular bacteria constitute a major class of pathogens for humans and animals. Their pathogenicity is linked to their ability to multiply inside a host cell. A set of virulence genes (virulome) is required for this intracellular lifestyle. Recent studies have shown that blocking the enzymes encoded by these virulence genes impairs intracellular multiplication of the pathogen. These specific factors could constitute a new set of possible targets for antimicrobial drugs. The potential advantages, pitfalls and challenges of a strategy that targets these virulence factors are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b10e8455e279e6efa8a3aa8d6d11c9 https://doi.org/10.1016/j.tim.2006.01.005 Zobrazit plný text záznamu Full Text from ScienceDirect