Potential Microbiological Risk Factors Associated With Periodontitis and Periodontal Health Disparities
| Autor: | Meng-Hsuan Ho, Hua Xie, Hsiu-Wan Meng, Sally Sheng, Laura Arsto, Qiuyin Cai, Jianming Hong, Tom Lu, Bing-Yan Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Streptococcus cristatus Immunology Virulence Dental plaque Microbiology Periodontal pathogen Cellular and Infection Microbiology Risk Factors racial and ethnic groups Medicine Humans microbial profiles Porphyromonas gingivalis periodontitis Retrospective Studies Original Research Periodontitis biology business.industry biology.organism_classification medicine.disease Health equity QR1-502 Infectious Diseases Cohort business |
| Zdroj: | Frontiers in Cellular and Infection Microbiology, Vol 11 (2021) Frontiers in Cellular and Infection Microbiology |
| ISSN: | 2235-2988 |
| DOI: | 10.3389/fcimb.2021.789919/full |
| Popis: | Periodontitis disproportionately affects different racial and ethnic populations. In this study, we used qPCR to determine and compare oral microbial profiles in dental plaque samples from 191 periodontitis patients of different ethnic/racial backgrounds. We also obtained the periodontal parameters of these patients retrospectively using axiUm and performed statistical analysis using SAS 9.4. We found that in this patient cohort, neighborhood median incomes were significantly higher among Caucasians Americans (CAs) than among African Americans (AAs) and Hispanic Americans (HAs). Levels of total bacteria and Porphyromonas gingivalis, a keystone periodontal pathogen, were not evenly distributed among the three groups. We confirmed our previous findings that Streptococcus cristatus reduces P. gingivalis virulence potential and likely serves as a beneficial bacterium. We also showed the ratio of S. cristatus to P. gingivalis to be significantly higher in CAs than in HAs and AAs. Our results suggest that higher levels of P. gingivalis and lower ratios of S. cristatus to P. gingivalis may contribute to periodontal health disparities. |
| Databáze: | OpenAIRE |
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