Neural Substrates of Psychotic Depression: Findings From the Global ECT-MRI Research Collaboration

Autor: Patrice Péran, Narcís Cardoner, Paul Hamilton, Akihiro Takamiya, Marta Cano, Mardien L. Oudega, Guido van Wingen, Pia Nordanskog, Anders Jorgensen, Willem B Bruin, Eric van Exel, Martin Balslev Jørgensen, Mathieu Vandenbulcke, Taishiro Kishimoto, Carles Soriano Mas, Annemiek Dols, Didi Rhebergen, Christopher C. Abbott, Olga Therese Ousdal, Pascal Sienaert, Ute Kessler, Louise Emsell, Robin Kämpe, Leif Oltedal, Filip Bouckaert, Olaf B. Paulson, Antoine Yrondi, Hauke Bartsch
Přispěvatelé: Graduate School, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Adult Psychiatry, Neurology, Psychiatry, Amsterdam Neuroscience - Neurodegeneration, APH - Aging & Later Life, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Schizophrenia bulletin, 48(2), 514-523. Oxford University Press
sbab122
Schizophrenia Bulletin
Takamiya, A, Dols, A, Emsell, L, Abbott, C, Yrondi, A, Soriano Mas, C, Jorgensen, M B, Nordanskog, P, Rhebergen, D, Van Exel, E, Oudega, M L, Bouckaert, F, Vandenbulcke, M, Sienaert, P, Peran, P, Cano, M, Cardoner, N, Jorgensen, A, Paulson, O B, Hamilton, P, Kampe, R, Bruin, W, Bartsch, H, Ousdal, O T, Kessler, U, Van Wingen, G, Oltedal, L & Kishimoto, T 2022, ' Neural Substrates of Psychotic Depression : Findings from the Global ECT-MRI Research Collaboration ', Schizophrenia Bulletin, vol. 48, no. 2, pp. 514-523 . https://doi.org/10.1093/schbul/sbab122
Schizophrenia Bulletin, 48(2), 514-523. Oxford University Press
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 0586-7614
Popis: Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71.7 in PMD and 70.2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed. Funding Agencies|Keio University Medical Science Fund [99-095-0007]; AMED [JP20dm0307102h0003]; Research Foundation Flanders (FWO) grantFWO [G0C0319N]; KU Leuven Fund [C24/18/095]; Sequoia Fund for Research on Ageing and Mental Health; National Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [MH125126, MH111826]; Carlos III Health InstituteInstituto de Salud Carlos III [CD20/00189]; Lundbeck FoundationLundbeckfonden; Western Norway Regional Health Authority [911986, 912238]
Databáze: OpenAIRE
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