Gut Seasons: Photoperiod Effects on Fecal Microbiota in Healthy and Cafeteria-Induced Obese Fisher 344 Rats
| Autor: | Verónica Arreaza-Gil, Iván Escobar-Martínez, Manuel Suárez, Francisca Isabel Bravo, Begoña Muguerza, Anna Arola-Arnal, Cristina Torres-Fuentes |
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| Rok vydání: | 2022 |
| Předmět: |
Male
seasonal rhythms obesity Nutrition and Dietetics gut microbiota Nutrition. Foods and food supply Gut microbiota Photoperiods Seasonal rhythms Obesity Cafeteria diet Photoperiod Diet High-Fat digestive system Gastrointestinal Microbiome Rats fluids and secretions photoperiods cafeteria diet Animals TX341-641 Seasons hormones hormone substitutes and hormone antagonists Food Science |
| Zdroj: | Nutrients, Vol 14, Iss 722, p 722 (2022) Nutrients; Volume 14; Issue 3; Pages: 722 |
| ISSN: | 2072-6643 |
| Popis: | Gut microbiota and biological rhythms are emerging as key factors in the modulation of several physiological and metabolic processes. However, little is known about their interaction and how this may affect host physiology and metabolism. Several studies have shown oscillations of gut microbiota that follows a circadian rhythmicity, but, in contrast, variations due to seasonal rhythms have not been sufficiently investigated yet. Thus, the goal of this study was to investigate the impact of different photoperiods, which mimic seasonal changes, on fecal microbiota composition and how this interaction affects diet-induced obesity development. To this aim, Fisher 344 male rats were housed under three photoperiods (L6, L12 and L18) and fed with standard chow diet or cafeteria diet (CAF) for 9 weeks. The 16S ribosomal sequencing of collected fecal samples was performed. The photoperiod exposure significantly altered the fecal microbiota composition under L18, especially in CAF-fed rats. Moreover, these alterations were associated with changes in body weight gain and different fat parameters. These findings suggest a clear impact of seasonal rhythms on gut microbiota, which ultimately translates into different susceptibilities to diet-induced obesity development. This is the first time to our knowledge that the photoperiod impact on gut microbiota composition has been described in an obesity context although further studies are needed in order to elucidate the mechanisms involved. |
| Databáze: | OpenAIRE |
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