Picenadol in a Large Multicenter Dental Pain Study
| Autor: | Stephen A. Cooper, L. Thomas Gallegos, Donald C. Reynolds, Rocco L. Brunelle, Paul J. Desjardins, David J. Goldstein, Gary E. Jeffers, Richard E. George, Gerald W. Gaston |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Analgesic Codeine Phosphate Placebo Bone and Bones Double-Blind Method Piperidines Humans Medicine Pharmacology (medical) Adverse effect Pain Measurement Analgesics Pain Postoperative Dose-Response Relationship Drug Codeine business.industry Equianalgesic Opioid Anesthesia Tooth Extraction Female Picenadol business medicine.drug |
| Zdroj: | Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 14:54-59 |
| ISSN: | 0277-0008 |
| DOI: | 10.1002/j.1875-9114.1994.tb02789.x |
| Popis: | Study Objective. To estimate the analgesic dose of picenadol hydrochloride equal to codeine 60 mg in a dental pain model. Design. Randomized, double-blind, parallel, dose-response study. Setting. Four university-based dental clinics. Patients. Four hundred eight adult patients with moderate or severe pain after extraction of one or more impacted molar teeth plus bone removal. Interventions. Patients received orally administered single doses of picenadol 15 and 30 mg, codeine phosphate 30 and 90 mg, or placebo. Methods. Single oral doses of picenadol 15 and 30 mg, an opioid agonist-antagonist, were compared with codeine 30 and 90 mg and placebo in 408 patients with moderate or severe pain from third molar extraction in a randomized, double-blind, parallel study. Assessments were performed for pain intensity, pain relief, and adverse events for up to 6 hours after drug administration. Main Results. Picenadol 30 mg and codeine 90 mg were more effective than placebo based on sum of pain intensity differences, total pain relief, peak pain relief, and duration of analgesia (p |
| Databáze: | OpenAIRE |
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