Delta-9-tetrahydrocannabinol during pregnancy in the rat: Effects on development of RNA, DNA, and protein in offspring brain
| Autor: | Brian L. G. Morgan, Donald E. Hutchings, Nancy K. Miller, Stephen C. Brake, Zoi Gamagaris |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Offspring medicine.medical_treatment Clinical Biochemistry Biology Toxicology Biochemistry Behavioral Neuroscience Pregnancy Internal medicine mental disorders Delta-9-tetrahydrocannabinol medicine Protein biosynthesis Animals Dronabinol Biological Psychiatry Brain Chemistry Pharmacology Dose-Response Relationship Drug organic chemicals Brain Proteins Rats Inbred Strains Embryo DNA medicine.disease Rats Endocrinology Animals Newborn Prenatal Exposure Delayed Effects Toxicity RNA Gestation Female Cannabinoid |
| Zdroj: | Pharmacology Biochemistry and Behavior. 31:365-369 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(88)90359-0 |
| Popis: | Either 15 or 50 mg/kg of delta-9-tetrahydrocannabinol (THC) was administered from Day 2 through Day 22 of gestation. Pair-fed and nontreated groups served as controls and all treated and control litters were fostered at birth to untreated dams. To determine the effects of THC on offspring brain development, DNA, RNA and protein values were determined at 7, 14, and 21 days of postnatal age. DNA and RNA levels appeared unaffected by THC but brain protein levels of the 50 mg/kg offspring were significantly lower than in the other groups at Day 7 and 14. This suggests that the high THC dose inhibited protein synthesis for at least the first 14 days of life. Subsequently, protein levels of the 50 mg/kg offspring increased rapidly so that there were no differences between any of the groups at 21 days of age. These findings for developing CNS parallel the delayed rate of somantic growth previously reported from our laboratory and suggest a transitory rather than a permanent effect of THC on both somatic and brain growth. We also found that THC produces a significant dose-related increase in the sex-ratio of live male-to-female offspring, a finding we have reported previously. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|