Elafin is a potent inhibitor of proteinase 3
| Autor: | Jens Lüdemann, Bert Utecht, Oliver Wiedow |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Serine Proteinase Inhibitors
Neutrophils Myeloblastin Molecular Sequence Data Biophysics Proteinase Inhibitory Proteins Secretory Human skin Biology Biochemistry Proteinase 3 Potency Humans Amino Acid Sequence Molecular Biology Serpins Hydrolysis Elastase Serine Endopeptidases Proteins Cell Biology Molecular biology Elastin Enzyme inhibitor biology.protein Elafin |
| Zdroj: | Biochemical and biophysical research communications. 174(1) |
| ISSN: | 0006-291X |
| Popis: | Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradation showing an IC 50 of 9.5 x 10(-9) M. Potency was found to be more than 100-fold higher as compared with antileukoprotease and eglin C. |
| Databáze: | OpenAIRE |
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