Beta- and gamma-melanocortins inhibit lipopolysaccharide induced nitric oxide production in mice brain
| Autor: | Liga Zvejniece, Jarl E. S. Wikberg, Olga Kirjanova, Maija Dambrova, Ivars Kalvinsh, Larisa Baumane, Edgars Liepinsh, Ruta Muceniece, Liga Krigere |
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| Rok vydání: | 2003 |
| Předmět: |
Lipopolysaccharides
Male endocrine system medicine.medical_specialty Lipopolysaccharide Central nervous system Inflammation Pharmacology Biology Nitric Oxide Nitric oxide chemistry.chemical_compound Mice gamma-MSH In vivo Internal medicine beta-MSH medicine Animals Molecular Biology Neuroinflammation Melanocortins Feedback Physiological Mice Inbred ICR integumentary system Dose-Response Relationship Drug General Neuroscience Electron Spin Resonance Spectroscopy Brain Disease Models Animal medicine.anatomical_structure Endocrinology chemistry alpha-MSH Neurology (clinical) Melanocortin medicine.symptom Inflammation Mediators hormones hormone substitutes and hormone antagonists Developmental Biology Signal Transduction |
| Zdroj: | Brain research. 995(1) |
| ISSN: | 0006-8993 |
| Popis: | The pro-opiomelanocortin-derived peptide alpha-melanocyte stimulating hormone (alpha-MSH) mediates many diverse physiological actions, including anti-inflammatory and immunomodulatory effects. However, little is known about the physiological roles of the other melanocortins, beta- and gamma-MSH. Here, we investigated the effects of melanocortin peptides in an in vivo neuroinflammation model. Six hours following intracisternal (i.c.) administration of 10 microg lipopolysaccharide (LPS) to mice a five-fold increase in the nitric oxide (NO) level was seen in the animals' brains, when detected by electron paramagnetic resonance (EPR). All tested melanocortins, alpha-, beta-, gamma1- and gamma2-MSH (0.001-10 nmol/mouse i.c.), dose dependently reduced the LPS induced increases in brain NO, with an order of effectiveness: beta-MSHor = gamma1-MSH=gamma2-MSHalpha-MSH. Our results suggest specialized functions of beta- and gamma-MSH melanocortins in inflammatory signal modulation in the brain. |
| Databáze: | OpenAIRE |
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