GluA and GluN receptors regulate the surface density of GluN receptor subunits in cultured neocortical interneurons
| Autor: | Dieter K. Meyer, A. Kerstin Lindemeyer, Thomas Wilmes, Wolfgang Nörenberg, Helga Sobottka |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
N-Methylaspartate
Patch-Clamp Techniques Down-Regulation Neocortex Receptors Cell Surface Stimulation Tetrodotoxin AMPA receptor Receptors N-Methyl-D-Aspartate Biochemistry Cellular and Molecular Neuroscience Downregulation and upregulation Interneurons Excitatory Amino Acid Agonists Animals Biotinylation Calcium Signaling Receptors AMPA Patch clamp Rats Wistar Receptor alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Cells Cultured Chemistry musculoskeletal neural and ocular physiology Immunohistochemistry Electrophysiological Phenomena Rats Cell biology nervous system NMDA receptor Nerve Net Algorithms |
| Zdroj: | Journal of Neurochemistry. 121:597-606 |
| ISSN: | 1471-4159 0022-3042 |
| DOI: | 10.1111/j.1471-4159.2012.07719.x |
| Popis: | J. Neurochem. (2012) 121, 597–606. Abstract In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca2+-permeable AMPA (GluA) receptors located on the interneurons decreased the response of GluN receptors. The reduction was caused by a decrease in the surface density of GluN1/GluN2B subunits. In contrast, stimulation of GluN receptors located on the interneurons enhanced the surface density of GluN1/GluN2B subunits. Both effects could be induced by network activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text