Shared T Cell Epitopes in Epithelial Tumors
| Autor: | G. E. Peoples, Roy Smith, Timothy J. Eberlein, Peter S. Goedegebuure, Ichiro Yoshino, David C. Linehan |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Lung Neoplasms
Receptor ErbB-2 T cell Immunology Breast Neoplasms Peptide Human leukocyte antigen In Vitro Techniques Biology Proto-Oncogene Mas Epithelium Antigen Antigens Neoplasm Carcinoma Non-Small-Cell Lung HLA-A2 Antigen Tumor Cells Cultured medicine Humans Cytotoxic T cell Ovarian Neoplasms chemistry.chemical_classification Immunity Cellular medicine.disease CTL medicine.anatomical_structure chemistry Cell culture Cancer research Female Peptides Ovarian cancer T-Lymphocytes Cytotoxic |
| Zdroj: | Cellular Immunology. 164:279-286 |
| ISSN: | 0008-8749 |
| DOI: | 10.1006/cimm.1995.1171 |
| Popis: | We have previously shown the importance of human leukocyte antigen (HLA)-A2 and the proto-oncogene HER2/neu in the T cell recognition of ovarian cancer. Since these proteins are ubiquitously expressed in epithelial-derived tumors, we have acid-eluted HLA-bound peptides from ovarian cancers, fractionated the peptides, and reconstituted T cell epitopes on the HLA-A2 + T2 cell line to determine if common tumor-associated antigens exist among HLA-A2 + , HER2/neu + epithelial cancers. We demonstrate that tumor-specific cytotoxic T lymphocytes (CTL) generated from tumor-infiltrating lymphocytes isolated from three ovarian, two breast, and two non-small-cell lung cancers recognize at least three of the same peptide fractions from multiple elutions. One of these peptide fractions co-elutes with a HER2/neu-derived peptide which has been shown recently to be recognized by these same CTL. These findings demonstrate that a common peptide-based tumor vaccine is theoretically possible for many different epithelial-derived cancers. |
| Databáze: | OpenAIRE |
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