Red cells, HLA and platelet antibody formation in patients with multiple transfusions
| Autor: | Tsung-Dao Lee, Jou-Yi Lyou, Alice Lee, Mo-Ping Chow, Hui-Yu Hu, Chien-Hui Yung, Jeong-Shi Lin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Blood Platelets
China Erythrocytes Taiwan Human leukocyte antigen Platelet Transfusion Biology Sepsis Blood product Chloroquine Antibody Specificity HLA Antigens Isoantibodies medicine Humans Platelet Hematology General Medicine Hemagglutination Tests Jaundice medicine.disease Cytotoxicity Tests Immunologic Red blood cell medicine.anatomical_structure Immunology biology.protein medicine.symptom Antibody Erythrocyte Transfusion medicine.drug |
| Zdroj: | Acta haematologica. 92(2) |
| ISSN: | 0001-5792 |
| Popis: | Totally 436 Chinese patients having received multiple transfusions of red cells and platelets on more than three occasions were screened for red cell antibodies. Twenty-six (6%) of them were positive. Anti-E, -Mia, and -c were the common alloantibodies. Nine patients were immunized during the period of regular transfusions, with a newly immunized rate of 2% (9/436). Among 436 patients, 387 were screened for HLA antibodies by lymphocytotoxicity test (LCT). The overall positive rate was 35%. Most of the antibodies identified were against the high-frequency HLA antigens in the Chinese population. About 10% of the LCT-positive cases reverted to negative state during the follow-up period. After chloroquine stripping of the target platelets, mixed passive hemagglutination assay was used to detect platelet antibodies other than HLA antibody. Fifty-eight of 161 cases (36%) were positive for platelet antibodies, but half of them disappeared within 1 month. Nineteen of the 58 patients had sepsis and 2 had jaundice. These findings suggested that HLA and platelet antibodies are common among Chinese, though their clinical significance and the role in platelet damage are doubtful. |
| Databáze: | OpenAIRE |
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