Cognitive and motor aspects of cancer‐related fatigue

Autor: Joseph A. Shrader, Alexander Ross, Li Rebekah Feng, Josephine Liwang, Saloni Kumar, Leorey N. Saligan, Jeniece Regan
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
radiation therapy
lcsh:RC254-282
03 medical and health sciences
Grip strength
cancer‐related fatigue
Cognition
0302 clinical medicine
Physical medicine and rehabilitation
medicine
Humans
Radiology
Nuclear Medicine and imaging
Effects of sleep deprivation on cognitive performance
Stroop interference
Cancer-related fatigue
Fatigue
Aged
Original Research
cognitive impairment
hand grip
Hand Strength
business.industry
Prostatic Neoplasms
Clinical Cancer Research
Cancer
Middle Aged
medicine.disease
prostate cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Test (assessment)
physical fatigue
Phenotype
030104 developmental biology
Physical Fatigue
Oncology
030220 oncology & carcinogenesis
Stroop Test
medicine.symptom
business
Stroop effect
Zdroj: Cancer Medicine, Vol 8, Iss 13, Pp 5840-5849 (2019)
Cancer Medicine
ISSN: 2045-7634
Popis: Background Cancer‐related fatigue (CRF) is a debilitating symptom frequently reported by patients during and after treatment for cancer. CRF is a multidimensional experience and is often solely assessed by self‐report measures. The goal of the study is to examine the physical and cognitive aspects of self‐reported CRF using a cognitive function test and a physical fatigue index in order to provide objective measures that can characterize the CRF phenotype. Methods A total of 59 subjects with nonmetastatic prostate cancer receiving external beam radiation therapy were included in the study. Fatigue was measured using the Functional Assessment of Cancer Therapy‐Fatigue (FACT‐F) questionnaire. Cognitive characteristics of CRF was measured using the Stroop Color‐Word Interference computerized test and the motor aspect of fatigue was measured using the static fatigue test using a handgrip dynamometer. Findings Functional Assessment of Cancer Therapy‐Fatigue scores significantly correlated with the Stroop Interference score, but not performance accuracy in all test conditions. Fatigued subjects exhibited a more rapid decline to 50% of maximal strength and increased static fatigue index in the handgrip test, whereas maximal grip strength was not affected. Conclusions The results suggest that CRF exhibits both cognitive and physical characteristics. Subjective fatigue was associated with increased time required to overcome cognitive interference, but not cognitive performance accuracy. Fatigued patients exhibited decreased physical endurance and the ability to sustain maximal strength over time. These objective measures may serve as valuable tools for clinicians to detect cognitive and physical impairment associated with CRF.
We found that cancer‐related fatigue was associated with both increased cognitive interference and decreased physical endurance. This suggests that the overall sense of tiredness reported by cancer patients is both cognitive and physical in nature.
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje