Contrast sensitivity impairment in drug-naïve Parkinson's disease patients associates with early cognitive decline
| Autor: | Joo Young Shin, Dalla Yoo, Jee Young Lee, Beomseok Jeon, Jeeyun Ahn, Sang Bin Hong |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Neurology Parkinson's disease media_common.quotation_subject Dermatology Neuropsychological Tests Contrast Sensitivity 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Contrast (vision) Humans Cognitive Dysfunction 030212 general & internal medicine Cognitive decline media_common Sleep disorder business.industry Cognition Parkinson Disease General Medicine medicine.disease Psychiatry and Mental health Drug-naïve Pharmaceutical Preparations Dementia Neurology (clinical) Neurosurgery business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 41(7) |
| ISSN: | 1590-3478 |
| Popis: | To investigate the contrast sensitivity function in drug-naive Parkinson’s disease (PD) patients and its predictive value with longitudinal follow-up data. We included newly diagnosed non-demented PD patients who performed contrast sensitivity test between 2013 and 2014. Contrast sensitivity function at drug-naive state in PD patients was compared with age-matched normal control data of our center. Correlation between contrast sensitivity function and parkinsonian motor and non-motor features including the Mini-Mental State Exam (MMSE) score at the time of diagnosis were analyzed by linear regression. With longitudinal follow-up data after initiating anti-parkinsonian therapy, the risk conferred on subsequent visual hallucinations and cognitive impairment requiring anti-dementia drugs was analyzed by dichotomizing PD group based on the initial contrast sensitivity function. Forty-eight patients were finally included, and mean follow-up periods were 43 months. Contrast sensitivity function in drug-naive PD patients was significantly worse than controls. Contrast sensitivity function correlated with sleep disturbance (p = 0.001) and global cognitive status reflected by the MMSE score (p = 0.020). It also associated with further decline in the MMSE during the follow-ups (p = 0.029). Patients with below average contrast sensitivity function at the time of diagnosis showed higher risk of cognitive decline requiring anti-dementia drugs (adjusted odds ratio = 4.68, p = 0.04) and of visual hallucinations (adjusted odds ratio = 12.54, p = 0.04) than those above average function during the follow-up. Contrast sensitivity impairment in drug-naive PD patients associates with clinical demand for therapeutic intervention of cognitive decline as well as development of visual hallucinations in the early course of the disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink