Non-Hodgkin’s lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH

Autor:	B Bressac-de-Paillerets, Marie-Agnès Dragon-Durey, Alain Bernheim, D Fauvet, C Leonard, A F Goguel, Roland Berger
Rok vydání:	1998
Předmět:	Male congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Myeloid Adolescent Chromosomal translocation Biology Polymerase Chain Reaction Translocation Genetic hemic and lymphatic diseases medicine Humans Child Chromosomes Artificial Yeast Anaplastic large-cell lymphoma In Situ Hybridization Fluorescence Nucleophosmin Breakpoint Cytogenetics Hematology medicine.disease Lymphoma Leukemia Myeloid Acute Leukemia medicine.anatomical_structure Oncology Child Preschool Chromosomes Human Pair 2 Myelodysplastic Syndromes Immunology Cancer research Chromosomes Human Pair 5 Female Chromosomes Human Pair 3 Lymphoma Large B-Cell Diffuse Gene Deletion
Zdroj:	Leukemia. 12:1159-1162
ISSN:	1476-5551 0887-6924
Popis:	The nucleophosmin (NPM) gene is involved in two recurrent translocations in hematological malignancies: t(2;5) (p23;q35) in anaplastic large cell lymphoma (ALCL) and t(3;5)(q25.1;q34-35) in myelodysplasia and acute non-lymphocytic leukemia (ANLL). Using eight YACs encompassing the 5q34-q35 region, we could easily detect these two translocations. In both types of translocation, probable unexpected deletions were also discovered downstream of the breakpoint at 5q35.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d399d1dc937c91ea9c9bd550107a9714 https://doi.org/10.1038/sj.leu.2401047 Zobrazit plný text záznamu Plný text ve formátu PDF