[Epicardial Transplantation of Cardiac Progenitor Cells Based Cells Sheets is More Promising Method for Stimulation of Myocardial Regeneration, Than Conventional Cell Injections]
| Autor: | E. I. Ratner, K. V. Dergilev, Z. I. Tsokolayeva, E. V. Parfyonova, I. B. Beloglazova |
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| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Pathology medicine.medical_specialty business.industry Regeneration (biology) Myocardium Stem Cells Cell 030204 cardiovascular system & hematology medicine.disease Transplantation Extracellular matrix Cell therapy 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Tissue engineering medicine Regeneration Myocardial infarction Progenitor cell Cardiology and Cardiovascular Medicine business 030304 developmental biology Stem Cell Transplantation |
| Zdroj: | Kardiologiia. 59(5) |
| ISSN: | 0022-9040 |
| Popis: | Today, transplantation of stem / progenitor cells is a promising approach for the treatment of heart diseases. The therapeutic potential of transplanted cells directly depends on the method of delivery to the myocardium, which determines their regenerative properties. It is important for the development of effective methods of cell therapy. In this paper, we performed a comparative study of efficacy of cardiac progenitor cell (CPC) transplantation by intramyocardial needle injections and by tissue engineering constructs (TEC) – “cell sheets” consisting of cells and their extracellular matrix. It has been shown, that transplantation of TEC in comparison with the intramyocardial delivery provides more extensive distribution and retains more proliferating cellular elements in the damaged myocardium, attenuates the negative cardiac remodeling of the left ventricle and promotes its vascularization. |
| Databáze: | OpenAIRE |
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