Ni-Catalyzed Reductive Arylalkenylation of Alkynes for the Selective Synthesis of Polysubstituted Naphthalenes

Autor: Meng-Qiang Zeng, Ke-Xin Feng, Bo-Lun Hu, Hai-Yong Tu, Xing-Guo Zhang
Rok vydání: 2022
Předmět:
Zdroj: Organic letters. 24(29)
ISSN: 1523-7052
Popis: A Ni-catalyzed reductive arylalkenylation of alkynes with 1-bromo-2-(2-chlorovinyl)arenes in the presence of zinc powder has been developed. This base-free cyclization provides a novel protocol for the selective synthesis of 2-trifluoromethyl naphthalenes and ethyl 2-naphthoates from simple starting materials in moderate to good yields with excellent tolerance of functional groups.
Databáze: OpenAIRE