Beneficial effects of riociguat on hemodynamic responses to exercise in CTEPH patients after balloon pulmonary angioplasty – A randomized controlled study

Autor: Hideaki Suzuki, Haruka Sato, Kotaro Nochioka, Masanobu Miura, Tatsuo Aoki, Satoshi Miyata, Hiroaki Shimokawa, Shigefumi Fukui, Saori Yamamoto, Yosuke Terui, Ryo Konno, Katsuya Kozu, Shunsuke Tatebe, Koichiro Sugimura, Nobuhiro Yaoita, Kimio Satoh
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
PEA
pulmonary endarterectomy
Haemodynamic response
mPAP
mean pulmonary arterial pressure
medicine.medical_treatment
CO
cardiac output
Chronic thromboembolic pulmonary hypertension
Hemodynamics
030204 cardiovascular system & hematology
PVR
pulmonary vascular resistance
Balloon
Riociguat
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
Angioplasty
medicine
Balloon pulmonary angioplasty
030212 general & internal medicine
CI
Cardiac index
PAWP
pulmonary arterial wedge pressure
Beneficial effects
Original Paper
HR
heart rate
business.industry
BP
Arterial blood pressure
BPA
Balloon pulmonary angioplasty
Riociguat
exercise response
lcsh:RC666-701
6MWD
6-min walk distance
Cardiology
CTEPH
Chronic thromboembolic pulmonary hypertension
RAP
right atrial pressure
PAH
pulmonary arterial hypertension
Cardiology and Cardiovascular Medicine
business
RVEF
right ventricular ejection fraction
medicine.drug
Zdroj: International Journal of Cardiology. Heart & Vasculature
International Journal of Cardiology: Heart & Vasculature, Vol 29, Iss, Pp 100579-(2020)
ISSN: 2352-9067
Popis: Background: Although balloon pulmonary angioplasty (BPA) improves symptoms and pulmonary hemodynamics in patients with chronic thromboembolic pulmonary hypertension (CTEPH), the effects of riociguat on hemodynamics and exercise capacity in patients after BPA remain to be elucidated. Methods and Results: This study was a single-center, prospective, randomized, open-label trial. From November 2015 to November 2018, we prospectively examined 21 patients with CTEPH (65 ± 9 years old, M/F 2/19) who showed hemodynamic improvement with mean pulmonary arterial pressure (mPAP)
Databáze: OpenAIRE
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