Discovery of 4-azaindoles as novel inhibitors of c-Met kinase

Autor:	John Robert Porter, Mark James Batchelor, Fabien Lecomte, Christoph Meier, Jean Keyaerts, Lloyd King, Jose M. Gascon-Simorte, James Thomas Reuberson, Alison Maloney, Kelly Le Riche, Jean Delgado, Mark Daniel Calmiano, Bénédicte Lallemand, Simon Lumb, Anne Marie Foley, Richard J. Franklin, Helen Edwards
Rok vydání:	2009
Předmět:	C-Met Indoles Stereochemistry Clinical Biochemistry Pharmaceutical Science Tumor cells Crystallography X-Ray Biochemistry chemistry.chemical_compound Structure-Activity Relationship Growth factor receptor Cell Line Tumor Drug Discovery Transferase Humans Computer Simulation Molecular Biology Protein Kinase Inhibitors chemistry.chemical_classification Kinase Organic Chemistry Proto-Oncogene Proteins c-met Enzyme chemistry Molecular Medicine Signal transduction
Zdroj:	Bioorganicmedicinal chemistry letters. 19(10)
ISSN:	1464-3405
Popis:	A series of 4-azaindole inhibitors of c-Met kinase is described. The postulated binding mode was confirmed by an X-ray crystal structure and series optimisation was performed on the basis of this structure. Future directions for series development are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3985a39d17773e1b2ec299ad573ae58 https://pubmed.ncbi.nlm.nih.gov/19369077 Zobrazit plný text záznamu Full Text from ScienceDirect