Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort
| Autor: | Philip E. Melton, Ann-Charlotte Iversen, Liv Cecilie Vestrheim Thomsen, Eric K. Moses, Maria Lisa Odland, Linda Tømmerdal Roten, Ottar Nygård, Ingvill Lyslo, Kjersti Tollaksen, Line Bjørge, Chen Sun, Kristin Melheim Strand, Rigmor Austgulen |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Gerontology phenotyping DM2 Physiology Download aCVD MEDLINE Mothers ComputingMilieux_LEGALASPECTSOFCOMPUTING Norwegian preeclampsia Pre-Eclampsia Pregnancy Medisinske Fag: 700 [VDP] Internal Medicine Humans Medicine family cohort License reproductive and urinary physiology Biological Specimen Banks phenotypic correlation Actuarial science Norway business.industry phenotypes Infant Newborn Creative commons Biobank Infant newborn female genital diseases and pregnancy complications language.human_language biobank heritability estimate Phenotype ORIGINAL PAPERS: Pre–eclampsia Infant Small for Gestational Age Cohort ComputingMethodologies_DOCUMENTANDTEXTPROCESSING language Female H2r Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Hypertension |
| ISSN: | 0263-6352 |
| DOI: | 10.1097/hjh.0000000000000696 |
| Popis: | Supplemental Digital Content is available in the text Objective: Preeclampsia is a complex genetic disease of pregnancy with a heterogenous presentation, unknown cause and potential severe outcomes for both mother and child. Preeclamptic women have increased risk for atherothrombotic cardiovascular disease. We aimed to identify heritabilities and phenotypic correlations of preeclampsia and related conditions in the Norwegian Preeclampsia Family Biobank. Methods: By applying a variance components model, a total of 493 individuals (from 138 families with increased occurrence of preeclampsia) were classified according to 30 disease-related phenotypes. Results: Of parous women, 75.7% (263/338) had experienced preeclampsia and 35.7% of women with and 22.4% without preeclampsia delivered children small for gestational age (SGA). We identified 11 phenotypes as heritable. The increased occurrence of preeclampsia was reflected by the presence [heritability (H2r) = 0.60)] and severity (H2r = 0.15) of preeclampsia and being born in a preeclamptic pregnancy (H2r = 0.25). Other heritable phenotypes identified included SGA (H2r = 0.40), chronic hypertension (H2r = 0.57), severity of atherothrombotic cardiovascular disease (H2r = 0.31), BMI (H2r = 0.60) and pulmonary disease (H2r = 0.91). The heritable phenotype preeclampsia overlapped with SGA (P = 0.03), whereas pulmonary disease was phenotypically correlated with atherothrombotic cardiovascular disease (P |
| Databáze: | OpenAIRE |
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