Nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP offered as cell substrate: spacing determines attachment and differentiation of neurons
| Autor: | Steffen Jaehrling, Karsten Thelen, G. Elisabeth Pollerberg, Tobias Wolfram |
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| Rok vydání: | 2009 |
| Předmět: |
Macromolecular Substances
Surface Properties Cellular differentiation Molecular Conformation Bioengineering Nanotechnology Materials Testing Cell Adhesion Animals General Materials Science Spectrin Particle Size Cell adhesion Cytoskeleton Neural Cell Adhesion Molecules Cells Cultured Neurons Tissue Engineering Cell adhesion molecule Chemistry Mechanical Engineering Cell Differentiation General Chemistry Adhesion Condensed Matter Physics Nanostructures body regions Membrane protein Biophysics Neural cell adhesion molecule Crystallization |
| Zdroj: | Nano letters. 9(12) |
| ISSN: | 1530-6992 |
| Popis: | The density/spacing of plasma membrane proteins is thought to be crucial for their function; clear-cut experimental evidence, however, is still rare. We examined nanopatterns biofunctionalized with cell adhesion molecule DM-GRASP with respect to their impact on neuron attachment and neurite growth. Data analysis/modeling revealed that these cellular responses improve with increasing DM-GRASP density, with the exception of one spacing which does not allow for the anchorage of a cytoskeletal protein (spectrin) to three DM-GRASP molecules. |
| Databáze: | OpenAIRE |
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