Effects of Metabolically Healthy and Unhealthy Obesity on Prolongation of Corrected QT Interval
| Autor: | Guowei Pan, Zhao Li, Yonghong Zhang, Liang Guo, Liqiang Zheng, Hongmei Yang, Yingxian Sun, Mark J. Pletcher, Xiaofan Guo, Shasha Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Rural Population medicine.medical_specialty China 030209 endocrinology & metabolism 030204 cardiovascular system & hematology QT interval Body Mass Index 03 medical and health sciences Electrocardiography 0302 clinical medicine Heart Rate Internal medicine medicine Humans Obesity Aged Aged 80 and over Metabolic Syndrome business.industry Corrected qt Prolongation Middle Aged medicine.disease Large sample Long QT Syndrome Endocrinology Cardiology Female Metabolic syndrome Cardiology and Cardiovascular Medicine business Metabolic profile |
| Zdroj: | The American journal of cardiology. 119(8) |
| ISSN: | 1879-1913 |
| Popis: | Although obesity and the metabolic syndrome (MS) often co-occur, many obese (OB) subjects have a favorable metabolic profile. It is unclear whether these factors independently influence cardiac electrophysiology including prolongation of the QT interval. We examined associations among obesity, MS, and prolonged corrected QT (QTc) interval in a large sample of Chinese research participants aged ≥35 years recruited from rural areas of Liaoning Province during 2012 to 2013. Of the 11,209 participants, 6,364 (56.8%) were nonobese and metabolically healthy (OB-/MS-), 2,853 (25.5%) were OB-/MS+, 493 (4.4%) were OB+/MS-, and 1,499 (13.4%) were OB+/MS+. Mean (±SD) QTc intervals were higher in OB-/MS+ (436.3 ± 24.3) and OB+/MS+ (436.6 ± 25.9) participants but not OB+/MS- participants (425.4 ± 24.0) than in OB-/MS- participants (426.8 ± 21.5, p0.001), and the prevalence of QTc prolongation was higher in OB-/MS+ and OB+/MS+ participants (adjusted odds ratios [aOR] 1.68, 95% confidence interval [CI] 1.52 to 1.85; aOR 1.92, 95% CI 1.69 to 2.17, respectively) compared with OB-/MS- group but not in OB+/MS- participants (aOR 0.92, 95% CI 0.73 to 1.15). Prevalence increased with each MS component (aOR 1.27, 95% CI 1.22 to 1.32) but not with body mass index (aOR 1.01, 95% CI 0.99 to 1.02). In conclusion, prolonged QTc interval is associated with the MS and not independently associated with obesity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect