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Chemistry Department, Faculty of Science, Assiut University, Assiut, 71516, Egypt Manuscript received 1 February 1995, accepted 6 July 1995 Interaction of (p-benzimidazol-2-ylphenoxy)acetic acid hydrazide (1) with is othiocyanates affords acetylthiosemicarbazides (2a-c) which on cyclisation give 3a-c. Reaction of 3a with alkyl halide, ethyl chloroacetate and/or diethyl bromomalonate affords S-alkyl derivatives (4a-e). Condensation of 3a with p-substituted-phenacyl bromides gives 5a-c. Treatment of 3a with N-aryl and N-heterocyclic-2- chloroacetamides gives 6a-c. Reaction of 3a with CH2O in the presence of morpholine or p-toluidine affords the Mannich bases (7a,h). Cyclodehydration of 2a-c with phosphoric acid gives the thiadiazoles (8a-c). Interaction of 1 with CS2 gives 9 which is reacted with hydrazine hydrate to give 10. Condensation of 10 with aromatic aldehydes gives the azines (11a-1). Reaction of 10 with p-substitutedphenacyl bromide gives the uncyclised products 12a-c rather than cyclised ones 13a-c. Several compounds are screened for antibacterial activities. |
