Correlation between SACE (Subjective Angiographic Chemoembolization Endpoint) score and tumor response and its impact on survival after DEB-TACE in patients with hepatocellular carcinoma
| Autor: | Thomas Rodt, Martin Zeile, K. J. Oldhafer, Gregor A. Stavrou, Roland Brüning, Frank Wacker, Victoria Susanne Antonia Habbel |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Carcinoma Hepatocellular Urology medicine.medical_treatment Kaplan-Meier Estimate Gastroenterology 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Embolization Chemoembolization Therapeutic Response Evaluation Criteria in Solid Tumors Aged Epirubicin Retrospective Studies Aged 80 and over Univariate analysis Radiological and Ultrasound Technology Proportional hazards model business.industry Mortality rate Liver Neoplasms Hazard ratio Angiography Middle Aged medicine.disease Confidence interval Doxorubicin 030220 oncology & carcinogenesis Hepatocellular carcinoma Female Tomography X-Ray Computed business Progressive disease |
| Zdroj: | Abdominal Radiology. 44:3463-3479 |
| ISSN: | 2366-0058 2366-004X |
| Popis: | To asses angiographic and computed tomographic success criteria during and after transcatheter arterial drug-eluting bead chemoembolization (DEB-TACE) in patients with hepatocellular carcinoma (HCC) and its impact on progression-free survival (PFS) and overall survival (OS). In this retrospective single-center study, 50 patients with unresectable HCC having undergone DEB-TACE from January 2010 to July 2015 were assessed. The angiographic endpoint was classified by Subjective Angiographic Chemoembolization Endpoint (SACE) scale. Relative tumor density in arterial (DArt) and portal venous phase (DPV) computed tomography post- versus pre-DEB-TACE were calculated, respectively. Tumor response according to modified Response Criteria in Solid Tumors (mRECIST) was assessed. Univariate Kaplan–Meier and Cox regression analysis were carried out. SACE scores I, II, III, and IV were found in 1 (2%), 20 (40%), 15 (30%), and 14 (28%) patients, respectively. Median OS and PFS were 14.2 and 5.5 months, respectively. Death rates at 6 months, 1 year and 2 years were 24%, 38%, and 52%, respectively. SACE score during DEB-TACE significantly correlated with local and overall mRECIST results (local: p |
| Databáze: | OpenAIRE |
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