Evidence for the transfer of methadone and EDDP by sweat to children’s hair
| Autor: | Hilke Andresen-Streichert, Axel Klee, Tobias Kieliba, Justus Beike, Markus A. Rothschild, Katharina Feld, Patrick Dahm |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Pyrrolidines Contact time Physiology Sweat patch 01 natural sciences Gas Chromatography-Mass Spectrometry Pathology and Forensic Medicine SWEAT 03 medical and health sciences 0302 clinical medicine Tandem Mass Spectrometry Sweat patches Germany medicine Humans 030216 legal & forensic medicine Positive test Methadone to EDDP ratio Child Sweat Children integumentary system business.industry 010401 analytical chemistry Correction Middle Aged 0104 chemical sciences Oral ingestion medicine.anatomical_structure Hair Analysis Scalp Female Original Article Opiate business Methadone Chromatography Liquid medicine.drug Hair |
| Zdroj: | International Journal of Legal Medicine Int J Legal Med |
| ISSN: | 1437-1596 0937-9827 |
| Popis: | In cases where there is a question as to whether children have come into contact with drugs, examinations of their scalp hair are frequently carried out. Positive test results are often discussed in the forensic community due to the various possible modes via which drugs and their metabolites can be incorporated into the hair. These include drug uptake by the child (e.g. oral ingestion or inhalation), but also contamination of hair via contact with the sweat from drug users. In this study, the possibility of methadone and its metabolite EDDP being incorporated into children’s hair by contact with sweat from persons undergoing opiate maintenance therapy (methadone) was examined. The transfer of methadone and EDDP via sweat from methadone patients (n = 15) to children’s hair was simulated by close skin contact of drug-free children’s hair, encased in mesh-pouches, for 5 days. Sweat-collecting patches (hereafter referred to as ‘sweat patches’) were applied to the test persons’ skin. One strand of hair and one sweat patch were collected daily from each patient. Analyses were performed using GC–MS/MS (hair) and LC–MS/MS (serum, sweat patches). After 4 days of skin contact, methadone was detectable in the formerly drug-free hair strands in all 15 study participants. EDDP was detectable in 34 of 75 hair strands, with the maximum number of positive results (11 EDDP-positive hair strands) being detected after 5 days. These results show that transfer of methadone and EDDP to drug-free hair is possible through close skin contact with individuals taking part in methadone substitution programmes. A correlation between serum concentration, sweat concentration and substance concentration in hair strands could not be demonstrated, but a tendency towards higher concentrations due to longer contact time is clearly evident. |
| Databáze: | OpenAIRE |
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