The Role of Multidetector Computed Tomography and the Forced Oscillation Technique in Assessing Lung Damage in Adults With Cystic Fibrosis
| Autor: | Letícia da Silva Lacerda, Alan Ranieri Medeiros Guimarães, Roberto Mogami, Mônica de Cássia Firmida, Agnaldo José Lopes, Alysson R. Carvalho, Pedro Lopes de Melo, Marcos Cesar Santos de Castro |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pulmonary and Respiratory Medicine
Spirometry Adult Male Cystic Fibrosis medicine.medical_treatment Critical Care and Intensive Care Medicine 030218 nuclear medicine & medical imaging Pulmonary function testing 03 medical and health sciences Young Adult 0302 clinical medicine Forced Oscillation Technique Hounsfield scale Multidetector Computed Tomography Medicine Plethysmograph Humans Lung volumes Chest wall oscillation Lung Plethysmography Whole Body medicine.diagnostic_test business.industry Total Lung Capacity General Medicine respiratory system Chest Wall Oscillation Respiratory Function Tests Residual Volume medicine.anatomical_structure Cross-Sectional Studies 030228 respiratory system Female business Nuclear medicine Lung Volume Measurements |
| Zdroj: | Respiratory care. 63(4) |
| ISSN: | 1943-3654 |
| Popis: | BACKGROUND: With increased survival rates and the consequent emergence of an adult population with cystic fibrosis (CF), developing novel tools for periodic evaluations of these patients has become a new challenge. Thus, we sought to determine the contribution of lung-volume quantification using multidetector computed tomography (CT) in adults with CF and to investigate the association between structural changes and functional abnormalities. METHODS: This was a cross-sectional study in which 21 adults with CF and 22 control subjects underwent lung-volume quantification using multidetector CT. Voxel densities were divided into 4 bands: −1,000 to −900 Hounsfield units (HU) (hyperaerated region), −900 to −500 HU (normally aerated region), −500 to −100 HU (poorly aerated region), and −100 to 100 HU (non-aerated region). In addition, all participants performed pulmonary function tests including spirometry, body plethysmography, diffusion capacity for carbon monoxide, and the forced oscillation technique. RESULTS: Adults with CF had more non-aerated regions and poorly aerated regions with lung-volume quantification using multidetector CT than controls. Despite these abnormalities, total lung volume measured by lung-volume quantification using multidetector CT did not differ between subjects and controls. Total lung capacity (TLC) measured by body plethysmography correlated with both total lung volume (rs = 0.71, P CONCLUSIONS: In adults with CF, lung-volume quantification using multidetector CT can destimate the lung volumes of compartments with different densities and determine the aerated and non-aerated contents of the lungs; furthermore, lung-volume quantification using multidetector CT is clearly related to pulmonary function parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|