Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations
| Autor: | Ioan A Balea, Mircea Dragoteanu, Liliana A Dina, Ioana Grigorescu, Cecilia Piglesan, Stefan Tamas, Sabin O Cotul |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty congenital hereditary and neonatal diseases and abnormalities Cirrhosis Adolescent Hemodynamics Chronic liver disease Scintigraphy Gastroenterology Severity of Illness Index Liver disease Clinical Research Internal medicine Severity of illness Hypertension Portal Medicine Humans Portasystemic Shunt Surgical Stage (cooking) Radionuclide Imaging Aged Aged 80 and over medicine.diagnostic_test business.industry Liver Diseases General Medicine respiratory system Middle Aged medicine.disease respiratory tract diseases Liver Regional Blood Flow Case-Control Studies Chronic Disease Portal hypertension Female Nuclear Medicine business |
| Zdroj: | World journal of gastroenterology. 14(24) |
| ISSN: | 1007-9327 |
| Popis: | To explore portal hypertension and portosystemic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynamics.Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angioscintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters, the liver transit time (LTT) and the circulation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal inflow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS.The normal LTT value was 24 +/- 1 s. Abnormal LTT had PPV = 100% for CLD. 27 non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 +/- 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI5% (P0.01). PRSI30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the classification of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s, PRSI5%). In stage 1, LTT is increased, while PRSI remains normal. In stage 2, LTT is decreased between 16 s and 23 s, whereas PRSI is increased between 5% and 10%. In stage 3, PRSI is increased to 10%-30%, and LTT becomes undetectable by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD, stage 1 had PPV = 100% for non-cirrhotic CLD, stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis, stage 4 had PPV = 100% for cirrhosis.LTT allows the detection of early portal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. |
| Databáze: | OpenAIRE |
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