BAZ1B in Nucleus Accumbens Regulates Reward-Related Behaviors in Response to Distinct Emotional Stimuli
| Autor: | Jennifer A. Martin, Craig T. Werner, Li Shen, Rachael L. Neve, Caroline Dias, Ning-Yi Shao, Eric J. Nestler, Amy M. Gancarz, Zi-Jun Wang, David M. Dietz, Jacqui Rabkin, Diane M. Damez-Werno, HaoSheng Sun, Ezekiell Mouzon, Kimberly N. Scobie, Ja Wook Koo |
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| Přispěvatelé: | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences, Neve, Rachael L. |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Chromosomal Proteins Non-Histone media_common.quotation_subject Emotions Self Administration Motor Activity Nucleus accumbens Biology Social Environment Nucleus Accumbens Chromatin remodeling Epigenesis Genetic Rats Sprague-Dawley Social defeat Mice 03 medical and health sciences Cocaine Reward Animals Chronic stress media_common Adenosine Triphosphatases Social stress Behavior Animal General Neuroscience Addiction Articles Chromatin Rats Mice Inbred C57BL 030104 developmental biology Brain stimulation reward Neuroscience Stress Psychological Transcription Factors |
| Zdroj: | Society for Neuroscience |
| Popis: | ATP-dependent chromatin remodeling proteins are being implicated increasingly in the regulation of complex behaviors, including models of several psychiatric disorders. Here, we demonstrate thatBaz1b, an accessory subunit of the ISWI family of chromatin remodeling complexes, is upregulated in the nucleus accumbens (NAc), a key brain reward region, in both chronic cocaine-treated mice and mice that are resilient to chronic social defeat stress. In contrast, no regulation is seen in mice that are susceptible to this chronic stress. Viral-mediated overexpression ofBaz1b, along with its associated subunitSmarca5, in mouse NAc is sufficient to potentiate both rewarding responses to cocaine, including cocaine self-administration, and resilience to chronic social defeat stress. However, despite these similar, proreward behavioral effects, genome-wide mapping of BAZ1B in NAc revealed mostly distinct subsets of genes regulated by these chromatin remodeling proteins after chronic exposure to either cocaine or social stress. Together, these findings suggest important roles for BAZ1B and its associated chromatin remodeling complexes in NAc in the regulation of reward behaviors to distinct emotional stimuli and highlight the stimulus-specific nature of the actions of these regulatory proteins.SIGNIFICANCE STATEMENTWe show that BAZ1B, a component of chromatin remodeling complexes, in the nucleus accumbens regulates reward-related behaviors in response to chronic exposure to both rewarding and aversive stimuli by regulating largely distinct subsets of genes. |
| Databáze: | OpenAIRE |
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