Angiotensin-converting enzyme gene 2350 G/A polymorphism is associated with left ventricular hypertrophy but not essential hypertension
| Autor: | Zhi-Chu Cui, Xiang-Jun Yang, Min Pan, Hong-Mei Li, Zhi-Hua Liu, Xiao-Hong Yu, Jian-Hua Zhu, Wen-Ping Jiang |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Candidate gene Guanine Genotype Physiology Peptidyl-Dipeptidase A Essential hypertension Left ventricular hypertrophy Asian People Gene Frequency Internal medicine Internal Medicine medicine Humans Genetic Predisposition to Disease cardiovascular diseases Allele Allele frequency Polymorphism Genetic biology Adenine Angiotensin-converting enzyme Middle Aged medicine.disease Endocrinology Blood pressure Logistic Models Hypertension biology.protein Female Hypertrophy Left Ventricular Cardiology and Cardiovascular Medicine |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 30(1) |
| ISSN: | 0916-9636 |
| Popis: | The angiotensin-converting enzyme (ACE) gene (ACE) is one of the most studied candidate genes related to essential hypertension (EH) and left ventricular hypertrophy (LVH). ACE rs4343 synonymous coding polymorphism (2350 G/A) is known among the polymorphisms of this gene to have the most significant effect on plasma ACE concentrations. The aim of the present study was to investigate the association of this polymorphism with EH and LVH in 440 subjects (246 EH patients and 194 controls) from a Chinese Han population. In this study, 2350 G/A genotypes were identified by polymerase chain reaction and restriction digestion in all study participants, and left ventricular mass was assessed by 2-mode echocardiography in 178 untreated EH patients. There was no significant difference in either genotype distribution (p=0.3659) or allele frequency (p=0.1453) between EH and control groups. In addition, the 2350 G/A polymorphism had no effect on blood pressure in either controls or untreated EH patients. The distribution of genotypes differed significantly when patients with LVH were examined, i.e., 14.71% GG, 54.41% GA, and 30.88% AA patients had this complication, and 36.36% GG, 42.73% GA, and 20.91% AA patients did not (p=0.0070). The LVH patients had a higher A allele frequency (58.09%) than patients without LVH (42.27%) (p=0.0037). Logistic regression analysis revealed that the association between the A allele and LVH was independent of age, blood pressure, and body mass index. The relative risk of LVH in patients bearing the A allele (GA+AA group) compared with that of GG hypertensive patients was 3.31 (95% confidence interval [CI]: 1.43 to 7.68). These findings suggest an association between LVH and the 2350A allele in hypertensive patients. |
| Databáze: | OpenAIRE |
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