Treatment of oat-cell carcinoma of the lung in the community
| Autor: | Ronald Citronbaum |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty Vincristine Lung Neoplasms Cyclophosphamide medicine.medical_treatment Remission Spontaneous Antineoplastic Agents Lomustine Internal medicine medicine Carcinoma Humans Carcinoma Small Cell Chemotherapy Lung business.industry Combination chemotherapy Middle Aged Oat cell carcinoma medicine.disease Radiation therapy medicine.anatomical_structure Doxorubicin Pediatrics Perinatology and Child Health Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Medical and Pediatric Oncology. 4:363-366 |
| ISSN: | 1096-911X 0098-1532 |
| DOI: | 10.1002/mpo.2950040413 |
| Popis: | Nine patients with "limited" (thoracic) small-cell lung carcinoma were treated with combined chemotherapy and radiotherapy (involved field and prophylactic whole brain). Induction drugs were Vincristine, Adriamycin, and Cyclophosphamide; and Cyclophosphamide, Vincristine, and CCNU for maintenance. Eight out of nine patients (89%) continue NED at a median follow-up time of 12 months. This group is compared to 21 patients with more extensive disease and 6 patients with limited disease using various other regimens. Median survival in the extensive group was 5 months and 8 months for the limited-diseased group treated with single agents. Intensive combination chemo-irradiation therapy is safe and highly effective in patients with limited oat-cell carcinoma of the lung, and leads to prolonged disease-free survival. |
| Databáze: | OpenAIRE |
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