Effects of pre-extraction intermittent PTH administration on extraction socket healing in bisphosphonate administered ovariectomized rats
| Autor: | In Ho Cha, Hyo Won Jang, Jung In Kim, Jae-Young Kim |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system
Science Ovariectomy medicine.medical_treatment Dental diseases Parathyroid hormone Dentistry 030209 endocrinology & metabolism Bone healing Pre extraction Article Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine stomatognathic system medicine Oral diseases Animals Tooth Socket Saline Wound Healing Multidisciplinary Diphosphonates business.industry Extraction (chemistry) X-Ray Microtomography 030206 dentistry Bisphosphonate Rats stomatognathic diseases Parathyroid Hormone Tooth Extraction Ovariectomized rat Medicine Female Bisphosphonate therapy business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2045-2322 |
| Popis: | The purpose of this study was to investigate the effect of administering intermittent parathyroid hormone (iPTH) before tooth extraction versus after tooth extraction on the risk of developing MRONJ in experimental animal model. Twenty-five ovariectomized rats received 6 weeks of bisphosphonate therapy. They were classified into 3 groups, based on the timing of the medication, as Control, Pre-PTH and Post-PTH groups. For Control group, normal saline was administered before and after tooth extraction. iPTH was administered during 4 weeks before tooth extraction for Pre-PTH group and after tooth extraction for Post-PTH group. The animals were euthanized 8 weeks after tooth extraction. Macroscopic, histological, micro-computed tomography (micro-CT), and histomorphometric examinations were conducted. The incidences of impaired healing were 11.11% both in Pre-PTH and Post-PTH groups, which was lower than the Control group (42.86%). Bone healing in the extraction socket, based on micro-CT and histomorphometry evaluations, was best in Post-PTH and worst in Control group. The Pre-PTH group showed moderate healing pattern. Despite of limitations in this study, the authors identified Pre-PTH group seems to have positive effect on extraction socket healing. With regard to timing, administering iPTH after tooth extraction was superior to applying it before tooth extraction. |
| Databáze: | OpenAIRE |
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