| Autor: |
Shih-Chin Cheng, Peter M.T. Deen, Hendrik G. Stunnenberg, Joost H.A. Martens, Jessica Quintin, Robert A. Cramer, Kelly M. Shepardson, Sadia Saeed, Rob J.W. Arts, Nagesha Appukudige Rao, Brian M. J. W. van der Veer, Cisca Wijmenga, Yang Li, Colin Logie, Frank L. van de Veerdonk, Ramnik J. Xavier, Ganesh R. Manjeri, Vinod Kumar, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Daniela C. Ifrim, Mihai G. Netea, Luke A. J. O'Neill, Leo A. B. Joosten, Peter H.G.M. Willems, Ali Aghajanirefah, Aylwin Ng |
| Přispěvatelé: |
Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Radboud University Medical Center [Nijmegen], Geisel School of Medicine at Dartmouth, Radboud university [Nijmegen], University Medical Center Groningen [Groningen] (UMCG), National and Kapodistrian University of Athens (NKUA), Trinity College Dublin, Massachusetts General Hospital [Boston], Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston] |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
|
| Zdroj: |
Science, 345(6204):1250684. AMER ASSOC ADVANCEMENT SCIENCE
Science
Science, American Association for the Advancement of Science, 2014, 345 (6204), pp.1250684-1250684. ⟨10.1126/science.1250684⟩
Science, 345, 6204, pp. 1250684
Science, 345, 1250684 |
| ISSN: |
0036-8075
1095-9203 |
| Popis: |
A BLUEPRINT of immune cell development To determine the epigenetic mechanisms that direct blood cells to develop into the many components of our immune system, the BLUEPRINT consortium examined the regulation of DNA and RNA transcription to dissect the molecular traits that govern blood cell differentiation. By inducing immune responses, Saeed et al. document the epigenetic changes in the genome that underlie immune cell differentiation. Cheng et al. demonstrate that trained monocytes are highly dependent on the breakdown of sugars in the presence of oxygen, which allows cells to produce the energy needed to mount an immune response. Chen et al. examine RNA transcripts and find that specific cell lineages use RNA transcripts of different length and composition (isoforms) to form proteins. Together, the studies reveal how epigenetic effects can drive the development of blood cells involved in the immune system. Science , this issue 10.1126/science.1251086 , 10.1126/science.1250684 , 10.1126/science.1251033 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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