Effect of rescue fractional microablative CO2 laser on symptoms and sexual dysfunction in women affected by vulvar lichen sclerosus resistant to long-term use of topic corticosteroid: a prospective longitudinal study
| Autor: | Giuseppe De Placido, Tiziana Pagano, Carlo Alviggi, Luisa Avino, Alessandro Conforti, Cira Buonfantino, Roberta Vallone, Francesco Sopracordevole, Francesco Schettini, Alessandra Gallo |
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| Přispěvatelé: | Pagano, T., Conforti, A., Buonfantino, C., Schettini, F., Vallone, R., Gallo, A., Avino, L., Alviggi, C., De Placido, G., Sopracordevole, F. |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Visual analogue scale General Mathematics 030209 endocrinology & metabolism Lichen sclerosus Vulvar Lichen Sclerosus law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Longitudinal Studies Prospective Studies Prospective cohort study Glucocorticoids Aged Clobetasol 030219 obstetrics & reproductive medicine business.industry Applied Mathematics Obstetrics and Gynecology Middle Aged medicine.disease Sexual Dysfunction Physiological Sexual dysfunction Lasers Gas Itching Female Menopause medicine.symptom Sexual function business |
| Zdroj: | Menopause. 27:418-422 |
| ISSN: | 1530-0374 |
| Popis: | OBJECTIVE: The objective of this study was to evaluate the efficacy of rescue fractional microablative CO2 laser treatment in women with severe symptoms and sexual dysfunction related to lichen sclerosus not responsive to long-term ultra-potent topical corticosteroid treatment. METHODS: Consecutive eligible women with lichen sclerosus referred to our unit who received fractional microablative CO2 laser treatment after failure of ultra-potent topical corticosteroid treatment were enrolled in the study. The diagnosis was confirmed by histological assessment in all cases. Patients underwent two cycles of CO2 laser every 30 to 40 days. The severity of lichen sclerosus-related symptoms, sexual function, and procedure discomfort were evaluated with a visual analog scale in the same individual at baseline, after completion of each treatment cycle. Follow-up visits were scheduled during each treatment cycle and at least 1 month after completion of the treatment. The Friedman ANOVA test was used to evaluate differences in the visual analog scale scores of each symptom during treatment. RESULTS: A total of 100 patients with vulvar lichen sclerosus were screened, 40 of whom fulfilled the eligibility criteria. We found a significant improvement in vulvar itching (χ [2] = 31,182, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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