A prospective, multicenter head-to-head comparative study in patients with primary high-risk prostate cancer investigating the bone lesion detection of conventional imaging and 18F-PSMA-PET/CT

Autor: Y.J.L. Bodar, W.I. Luining, B. Keizer, D. Meijer, A. Vellekoop, M. Schaaf, N.H. Hendrikse, R.J.A. Van Moorselaar, D.E. Oprea-Lager, A.N. Vis
Přispěvatelé: Urology, Radiology and nuclear medicine, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, AII - Cancer immunology, AII - Inflammatory diseases
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Bodar, Y J L, Luining, W I, Keizer, B, Meijer, D, Vellekoop, A, Schaaf, M, Hendrikse, N H, van Moorselaar, R J A, Oprea-Lager, D E & Vis, A N 2023, ' A prospective, multicenter head-to-head comparative study in patients with primary high-risk prostate cancer investigating the bone lesion detection of conventional imaging and 18F-PSMA-PET/CT ', Urologic Oncology: Seminars and Original Investigations, vol. 41, no. 4, pp. 205.e17-205.e24 . https://doi.org/10.1016/j.urolonc.2022.12.006
Urologic Oncology: Seminars and Original Investigations, 41(4), 205.e17-205.e24. Elsevier Inc.
ISSN: 1078-1439
Popis: Purpose: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an emerging staging tool for patients with primary high-risk prostate cancer (PCa). Patients with primary metastatic disease are staged using PSMA-PET/CT imaging, while previously published randomized clinical trials relied on conventional imaging (i.e., bone scintigraphy (BS) results. The aim of this study was to compare the ability of bone metastatic lesion detection and changes in staging for 18F-PSMA-PET/CT versus BS in high-risk PCa patients. Methods: 79 patients with high-risk PCa were prospectively staged using BS and subsequent 18F-PSMA-PET/CT before initial therapy. Patients who presented with a BS showing no metastases represented Group 1, and patients with a BS showing low-volume disease according to the CHAARTED criteria (18F-PSMA-PET/CT occurred only infrequently. Moreover, 18F-PSMA-PET/CT resulted in both upstaging and downstaging in a substantial subset of patients with low-volume metastatic disease on BS. Treatment changes occurred in almost 20% of cases depending on imaging results.
Databáze: OpenAIRE
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