Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

Autor:	Chen-Chen Chen, Yi-Ming Li, Yi-Chao Huang, Chao-Jian Guan, Qing-Xiang Guo, Xiang-Long Tan
Rok vydání:	2015
Předmět:	Fluorenes Hot Temperature biology Chemistry Air Organic Chemistry Kinetics Amides Biochemistry Combinatorial chemistry Dioxanes chemistry.chemical_compound Solid-phase synthesis Ubiquitin Amide Solvents biology.protein Solid-Phase Synthesis Techniques Physical and Theoretical Chemistry Peptides
Zdroj:	Organic & Biomolecular Chemistry. 13:1500-1506
ISSN:	1477-0539 1477-0520
Popis:	In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection. For the Hmsb-based backbone amide protection, an optimized acyl shift condition using 1,4-dioxane was discovered. The efficiency and robustness of the protocol was validated in the course of preparation of classical difficult peptides and ubiquitin protein segments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d380548df21ca4684911a9d7aca7730f https://doi.org/10.1039/c4ob02260b Zobrazit plný text záznamu